منابع مشابه
New approaches to sepsis: molecular diagnostics and biomarkers.
Sepsis is among the most common causes of death in hospitals. It arises from the host response to infection. Currently, diagnosis relies on nonspecific physiological criteria and culture-based pathogen detection. This results in diagnostic uncertainty, therapeutic delays, the mis- and overuse of antibiotics, and the failure to identify patients who might benefit from immunomodulatory therapies....
متن کاملMicrofluidic blood sample preparation for rapid sepsis diagnostics
Sepsis, commonly referred to as blood poisoning, is a serious medical condition characterized by a whole-body inflammatory state caused by microbial infection. Rapid treatment is crucial, however, traditional culturebased diagnostics usually takes 2-5 days. The overall aim of the thesis is to develop microfluidic based sample preparation strategies, capable of isolating bacteria from whole bloo...
متن کاملPrecision medicine, technologies, and molecular diagnostics
Introduction: Genetics, cellular and molecular medicines are cutting-edge sciences and technologies that play an important role in improving human health and quality of life. In addition, medical and biological sciences have clearly shown that the onset of diseases differs from person to person due to their different genetic profiles and variations in molecular basis. Therefore, it is feasible ...
متن کاملBench-to-bedside review: Future novel diagnostics for sepsis - a systems biology approach
The early, accurate diagnosis and risk stratification of sepsis remains an important challenge in the critically ill. Since traditional biomarker strategies have not yielded a gold standard marker for sepsis, focus is shifting towards novel strategies that improve assessment capabilities. The combination of technological advancements and information generated through the human genome project po...
متن کاملA Novel Sample Preparation Concept for Sepsis Diagnostics Using High Frequency Electric Fields
Despite their high potential to replace the time consuming gold standard blood culture for infection diagnosis from whole blood, molecular biology based techniques often lack sensitivity and specificity due to the high human background in complex biological samples such as blood. Concerning the realization of a point-of-care device for sepsis diagnosis which would enable immediate targeted anti...
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ژورنال
عنوان ژورنال: Critical Care Medicine
سال: 2017
ISSN: 0090-3493
DOI: 10.1097/ccm.0000000000002117